Factorial Study of Metoprolol Succinate TOPROL-XL (324A)

• Status: Completed
• Trial end date: 2004-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to determine if treatment with the combination of metoprolol succinate and hydrochlorothiazide is more effective at lowering blood pressure than treatment with either of the two drugs alone. The study will also determine which combined doses of metoprolol succinate and hydrochlorothiazide are most effective at lowering blood pressure (without unacceptable side effects), and whether it is possible to combine both drugs in a single tablet to simplify blood pressure treatment.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: AstraZeneca
• Treatments: Hydrochlorothiazide; Metoprolol

Criteria

Inclusion Criteria:

• Diastolic blood pressure between 95 and 114 mm at screening and start of treatment

Exclusion Criteria:

• Significant conditions which in the opinion of the investigator place the subject at undue risk, eg Renal impairment, hepatitis

• Known secondary causes of hypertension, eg, Cushing's syndrome, renal artery stenosis, pheochromocytoma, hyperaldosteronism

• Systolic blood pressure greater or equal to 180 mm Hg at start of trial