Overview

Factors Affecting Post-transplant Cyclophosphamide (PTCy) Efficacy

Status:
Suspended
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
This study will examine the influence of donor and recipient pharmacogenetics (PG), drug pharmacokinetics (PK), and T cell phenotypes and how it may permit a tailored dosing strategy to improve the therapeutic index of post-transplant cyclophosphamide (PTCy) and optimize the graft versus tumor effect, while minimizing acute and chronic graft versus host disease (GVHD).
Details
Lead Sponsor:
Atrium Health
Carolinas Healthcare System
Treatments:
Cyclophosphamide