Failure Rate of GLyburide And Metformin Among Gestational Diabetics

• Status: Withdrawn
• Trial end date: 2018-05-10
• Target enrollment: 0
• Participant gender: Female

Summary

A pragmatic, comparative effectiveness trial of glyburide versus metformin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Treatments: Glyburide; Hypoglycemic Agents; Metformin

Criteria

Inclusion Criteria:

We will include women between 20 and 34 weeks gestational age, with a diagnosis of GDM as per the following criteria:

• 1 hour Glucose tolerance test of >130 mg/dl, followed by two abnormal values on 3 hour Glucose tolerance test, or:

• A single 1 hour Glucose tolerance test value of > 200 mg/dl, and:

• Failure to achieve glycemic control with diet and exercise or deemed to require pharmacological therapy as per physician's criteria

Exclusion Criteria:

• - Known renal impairment.

• Known hepatic disease.

• Pre-gestational diabetes.

• Known allergy to glyburide, metformin or sulfa drugs.