Family-mismatched/Haploidentical Donors Versus Matched Unrelated Donors
Status:
Unknown status
Trial end date:
2019-12-31
Target enrollment:
Participant gender:
Summary
This study will compare the clinical outcomes of transplants from
family-mismatched/haploidentical donors (FMT) with transplants from 8/8-matched unrelated
donor (MUT), which is a current gold standard donors when lacking of HLA-matched-siblings
1. Primary objectives: Overall survival of FMT may be similar to that of MUT
2. Secondary objectives:
i. Comparison of disease-free survival, relapse, non-relapse mortality, immune
reconstitution cytomegalovirus infection, and acute or chronic graft-versus-host disease
between FMT and MUT.
ii. Investigation of possible biomarkers related with above events after transplantation