Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Low-dose aspirin can prevent cerebral and cardiovascular accidents in individuals with
symptomatic atherothrombotic disease, but its use is frequently limited by gastrointestinal
side effects.
The position of H2-receptor antagonists as a step-down therapy after healing of peptic ulcer
or erosions by proton pump inhibitor is unclear.
The objective of this randomized, double blinded control study was to compare the efficacy of
high-dose famotidine with pantoprazole in the prevention of recurrent dyspeptic or
complicated ulcer/ erosions in patients taking low-dose aspirin