Fat Tolerance From Lipid Emulsion Infusion Packaged in Glass or Plastic
Status:
Terminated
Trial end date:
2007-04-01
Target enrollment:
Participant gender:
Summary
This will be a prospective, randomized trial to determine if differences exist in the
tolerance of lipid injectable emulsions in the neonatal intensive care unit (NICU). Lipid
injectable emulsions are an essential nutrient for neonatal growth and development.
Traditionally, lipid injectable emulsions have been commercially available in sterile glass
bottles, but in April of 2004, a new container was introduced as a sterile plastic bag. In
January, 2005, NICU personnel observed what appeared to be a higher than usual incidence of
hypertriglyceridemia. Upon further laboratory investigation of the lipid injectable emulsions
stored in glass bottles versus those in plastic, significant differences were noted in the
population of large-diameter fat globules by globule size analysis, reflective of a less
stable emulsion in plastic. The United States Pharmacopeia (USP) which sets the standards for
drug purity and safety in the U.S., and whose drug monographs are enforceable by the FDA, has
proposed to limit this large diameter fat globule population to a volume-weighted percent fat
greater than five micrometers or PFAT5 to be less than 0.05% of the total lipid
concentration. (At the present time, the USP monograph is not officially recognized, but is
on track for adoption in 2006.) Our preliminary analyses of four lots of 20% lipid injectable
emulsion packaged in glass to have a PFAT5 of 0.003±0.0008%, compared to an approximate
55-fold increase in the large-diameter fat globule population or 0.166±0.016% for an equal
number of products packaged in plastic. We hypothesize this difference may explain the recent
clinical observations. We will compare the incidence of hypertriglyceridemia in neonates
between lipids packaged in glass versus those in plastic. The study will attempt to discern
whether the differences in packaging influence the stability and subsequent tolerance of
lipid injectable emulsions.