Fatigue in Multiple Sclerosis: Evaluated With 3 MRI and Transcranial Magnetic Stimulation

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate fatigue in patients with multiple sclerosis (MS) and to determine the correlation between the symptom and cerebral changes.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Collaborator: The Danish Multiple Sclerosis Society
• Treatments: 3,4-diaminopyridine; 4-Aminopyridine; Amifampridine

Criteria

Inclusion Criteria:

• Relapsing remitting-multiple sclerosis (RR-MS) according to Poser criteria

• EDSS: max 3.5

• Right handed

• Normal function of the right hand

Exclusion Criteria:

• Disease interfering with MS

• Known dementia

• Drug or alcohol abuse

• Treatment with psychoactive drugs within one week before study entry

• Major changes of medical treatment within 3 weeks before study entry

• Attack within 4 weeks before study entry

• Pregnancy

• Conditions interfering with 3,4-diaminopyridine treatment

• Conditions interfering with MRI

• Conditions interfering with transcranial magnetic stimulation