Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.

• Status: Completed
• Trial end date: 2020-07-31
• Target enrollment: 0
• Participant gender: All

Summary

24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning paradigm during acquisition of functional magnetic resonance imaging (fMRI). OCD patients will be submitted to the paradigm at two timepoints: baseline and 4 weeks after treatment initiation with sertraline up to 200mg/day or maximum tolerated dosage. OCD patients are expected to demonstrate worsened extinction retention compared to healthy subjects at baseline. Sertraline treatment is expected to improve extinction retention compared to baseline and to normalize the brain regions being recruited with the conditioned stimuli presented during the recall phase.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Sao Paulo
• Treatments: Sertraline

Criteria

Inclusion Criteria:

Healthy controls

-willingness to participate in research

OCD patients

• willingness to participate in research

• main diagnosis of OCD (psychiatric clinical evaluation)

• minimum YBOCS (Yale Brown Obsessive-compulsive severity scale) score of 16 points

Exclusion Criteria:

Healthy controls

• any current psychiatric diagnosis according to evaluation using semi structured interview for DSM IV diagnoses (SCID I)

• any past psychiatric diagnoses except single major depression episode and simple phobia (evaluation by semi structure interview-SCID I)

• current use of psychotropic medications (last use has to be at least 3 months prior to study initiation)

• chronic use of any medications except vitamins and contraceptives

• MRI exclusionary criteria (metal implants, recently made tatoos, claustrophobia, etc)

• being pregnant

OCD patients

• comorbidity with neurodevelopmental disorders (autism, mental retardation), current psychotic disorders, current substance dependence or abuse, bipolar mood disorder according to evaluation using semi structured interview for DSM IV diagnoses (SCID I)

• current use of psychotropic medications (last use has to be at least 3 months prior to study initiation)

• MRI exclusion criteria(metal implants, recently made tatoos, claustrophobia, etc)

• being pregnant or at risk of becoming pregnant