Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.
Status:
Completed
Trial end date:
2020-07-31
Target enrollment:
Participant gender:
Summary
24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning
paradigm during acquisition of functional magnetic resonance imaging (fMRI). OCD patients
will be submitted to the paradigm at two timepoints: baseline and 4 weeks after treatment
initiation with sertraline up to 200mg/day or maximum tolerated dosage. OCD patients are
expected to demonstrate worsened extinction retention compared to healthy subjects at
baseline. Sertraline treatment is expected to improve extinction retention compared to
baseline and to normalize the brain regions being recruited with the conditioned stimuli
presented during the recall phase.