Feasibility Study of Interval Compressed Regimen Using Four-drugs for Osteosarcoma
Status:
Unknown status
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
The aim of the study is to test the feasibility of four-drug, interval-compressed regimen in
osteosarcoma.
Primary objective is to explore the toxicity and mortality related to treatment. Secondary
objectives are to examine tumor necrosis rates after neoadjuvant chemotherapy, and to
evaluate the usefulness of circulating cell-free DNA, survivin, or transforming growth
factor-beta1 levels as well as programmed cell death ligand 1 expression in tumor specimen as
a predictive or prognostic biomarker in osteosarcoma patients.
Phase:
Phase 2
Details
Lead Sponsor:
Byung-Kiu Park
Collaborators:
Chungnam National University Hospital Samsung Medical Center