Feasibility Trial of Pregnenolone for Posttraumatic Stress Disorder and Alcohol Use Disorder
Status:
Withdrawn
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Pregnenolone is a neurosteroid and an over-the-counter supplement that has shown promise in
clinical studies of stress-related disorders, such as anxiety, depression and posttraumatic
stress disorder (PTSD). Epidemiological studies suggest that patients with PTSD are at higher
risk of developing addiction, including alcohol use disorder (AUD).The following hypothesis
will be tested in this trial: pregnenolone is associated with a reduction in both PTSD
symptoms and the number of standard drinks per week in outpatients with PTSD and AUD.