Overview

Feasibility of Haploidentical Hematopoietic Stem Cell Transplantation Using CAMPATH-1H

Status:
Completed
Trial end date:
2008-02-01
Target enrollment:
Participant gender:
Summary
Many patients suffering various malignant and non-malignant diseases need hematopoietic stem cell transplantation from a healthy person. In the majority of cases there is no matched related or unrelated donor. Some researchers have been performed transplantation from semi-matched (haploidentical) related donors with relatively good results. Chinese researchers have been performed this kind of transplantation using CAMPATH-1H and their reports indicates good results. Chinese populations have more homogenous genetic background than Iranians. In this project, we are going to study the feasibility of this method of haploidentical transplantation in Iranian patients.
Phase:
Phase 1
Details
Lead Sponsor:
Tehran University of Medical Sciences
Treatments:
Alemtuzumab
Busulfan
Cyclophosphamide
Cyclosporine
Cyclosporins
Methotrexate