Feasibility of Imaging in the Treatment of Patients With Advanced Head and Neck Cancer

• Status: Completed
• Trial end date: 2015-09-15
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to obtain preliminary information on the potential of 99m Tc-EC-DG SPECT imaging to distinguish cancer from non cancer.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chicago

Criteria

Inclusion Criteria:

• Treatment naive patients with histologically proven cancer of the head and neck

• T4 primary tumor (all sites), N2 or N3 locoregional disease (all sites)

• At least one measurable site of disease

• At least 18 years of age

• Karnofsky performance status > or = 70% or ECOG <2

• Able to tolerate SPECT/CT imaging

• Adequate bone marrow function

• Adequate liver function

• Adequate renal function

• Written consent from patients

• Female patients of childbearing potential must have a negative pregnancy test within 0-7 days prior to the first SPECT study

Exclusion Criteria:

• Diabetics with insulin dependence or blood sugar levels >200 mg/dL prior to imaging

• Patient weight above the SPECT/CT table weight limit

• Pregnant and/or lactating female

• Unequivocal demonstration of metastatic disease

• Patients unwilling to or unable to comply with protocol