Feasibility of Pediatric Emergency Department-Initiated Treatment for Adolescents With Opioid Use Disorder

• Status: Not yet recruiting
• Trial end date: 2023-07-30
• Target enrollment: 0
• Participant gender: All

Summary

ED-initiated buprenorphine with brief intervention and facilitated referral to treatment has been shown to be highly successful in increasing treatment engagement rates and reducing opioid use among adults. It is unknown whether this intervention is similarly effective for adolescents with OUD. To rigorously examine this important clinical research question, it is first necessary to optimize this intervention for the adolescent population. In this R34 proposal, we will use the Assessment-Decision-Administration-Production-Topic Experts-Integration-Training-Testing (ADAPT-ITT) framework-a systematic method for intervention adaptation- to adapt (Aim 1) and test the feasibility (Aim 2) of a treatment strategy for adolescents that has been shown to effectively link adults with OUD to ongoing addiction treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, Davis
• Collaborators: University of Utah; Yale University
• Treatments: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Naloxone

Criteria

Inclusion Criteria:

1. 13 years-old up to their 18th birthday on day of enrollment

2. Meet DSM-5 criteria for moderate/severe opioid use disorder;

3. Have a urine toxicology test positive for opioids, oxycodone, or buprenorphine (non-prescribed by history)

4. Can provide information for 2 reliable contacts that the study staff can contact in the case the study participant cannot be reached

Exclusion Criteria:

1. Have a urine toxicology test positive for methadone;

2. Unable to provide consent due to critical illness or reduced capacity

3. In jail/prison or in police custody;

4. Under the guardianship of child protective services;

5. Requires opioid medications for a currently present chronic pain condition;

6. Transferred from the ED to an inpatient unit prior to being able to provide consent;

7. Already enrolled in formal OUD treatment with medications with intent to return to the treatment program after ED discharge; or

8. Previously enrolled in the current study