Febrile Urinary Tract Infection Randomized Short Treatment Trial

• Status: Completed
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a 7-day duration of antibiotic treatment of febrile urinary tract infection (FUTI) is non inferior to 14-day standard duration of treatment in unselected population presenting at primary care or emergency department.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Leiden University Medical Center
• Collaborators: Bronovo Hospital; Diaconessenhuis Leiden; Groene Hart Ziekenhuis; Medical Center Haaglanden; Rijnland Hospital; Spaarne Gasthuis; Spaarne Ziekenhuis
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ciprofloxacin

Criteria

Inclusion Criteria:

• Competent patient aged 18 years or above

• One or more symptom(s) suggestive of urinary tract infection (dysuria, frequency or urgency*; perineal or suprapubic pain; costo-vertebral tenderness or flank pain)

• Fever (ear or rectal temp of 38.2 oC or higher, or axillary temp of 38 oC or higher), or history of feeling feverish with shivering or rigors in the past 24 hours

• Positive urine nitrate test and/or leucocyturia as depicted by positive leukocyte esterase test or microscopy

Exclusion Criteria:

• Known allergy to fluoroquinolones

• Female patients who are pregnant or lactating

• Patients with known polycystic kidney disease

• Patients on permanent renal replacement therapy (hemodialysis or peritoneal dialysis)

• Patients with history of kidney transplantation

• Residence outside country of enrolment

• Inability to speak or read Dutch

• Isolated causal uropathogen resistant to ciprofloxacin

• Renal abscess

• Chronic bacterial prostatitis

• Suspicion or evidence of any metastatic infectious foci