The intestinal microbiota plays a pivotal role in the maintenance of intestinal homeostasis
and protecting the gut against pathogens by competing for nutrients, creating the intestinal
biological barrier and modulating the host immune system.After the onset of acute
pancreatitis,the intestinal hypoperfusion and the release of inflammatory mediators result in
intestinal barrier dysfunction and intestinal bacteria dysbiosis.This leads to Bacterial and
endotoxin translocation, which may cause infectious complications which are major causes of
death in SAP patients.Recently,FMT was shown its efficacy in the treatment of
gastrointestinal(GI) diseases and non-GI disorders associated with Intestinal flora
disturbance by re-establishing the damaged Intestinal Bacteria homeostasis.However,the
mechanism by which FMT results in cure of diseases has been poorly understood.This study aims
to investigate the therapeutic potential of FMT for SAP patients with intestinal barrier
dysfunction.
Phase:
Phase 2
Details
Lead Sponsor:
The First Affiliated Hospital of Nanchang University