Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection
Status:
Completed
Trial end date:
2017-10-30
Target enrollment:
Participant gender:
Summary
Fecal microbiota transplantation (FMT) is acknowledged as a highly effective treatment for
recurrent Clostridium difficile infection (CDI). Usually single fecal infusion achieves
satisfactory cure rates of recurrent CDI). However, several retrospective studies show that
severe clinical picture of recurrent CDI is a risk factor for the failure of single-infusion
FMT, suggesting that multiple fecal infusions are required to cure this condition.
This is an open-label randomized clinical trial aiming to assess if multiple-infusion FMT is
more effective than single-infusion FMT in curing severe CDI