Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Hypotension is frequently encountered after induction of general anesthesia. It can be pronounced in elderly patients and can require administration of vasopressor agents including ephedrine and phenylephrine. Intraoperative hypotension, especially prolonged episodes, can contribute to an increase in morbidity and mortality in the postoperative period as suggested by some former studies. The investigators hypothesize that fentanyl can contribute to the decrease in blood pressure (BP) that is seen after induction of general anesthesia in older patients. This hypotension may be due to fentanyl blocking effect on the sympathetic nervous system.

This study will be the first one to examine the effect of fentanyl administration on blood pressure in elderly patients with induction of general anesthesia prior to the start of surgery. If the study shows that fentanyl contributes to hypotension during this period, it may lead to a change in practice and better patient outcomes and mortality rates.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Loyola University
• Treatments: Anesthetics; Fentanyl

Criteria

Inclusion Criteria:

• Age: 60 years and older

• Patients coming from home (including those who will be admitted post-operatively)

• Surgeries with general anesthesia alone or if combined with peripheral nerve blocks

• Patients must be seen at the Russo operating room at Loyola Medical Center (Maywood, IL)

Exclusion Criteria:

• Age less than 60

• Patient refusal

• Inpatient or emergency cases

• Patients having combined general anesthesia and epidural anesthesia

• Patients with a pre-induction mean arterial blood pressure (MAP) less than 50 or greater than 150

• Patients who will receive rapid sequence induction with succinylcholine

• Patients scheduled for cardiovascular surgery

• Patients scheduled for inhalational induction

• Patients with weight greater than 125 kg

• Patients with a history of chronic opioid use