The purpose of this study is to see if an enzyme in the body (5-alpha reductase, 5αR) is
important in controlling how the body handles sugar and fat. The investigators believe that
5αR is a crucial step in regulating these actions as well as controlling how insulin works in
the body but regulating the amount of steroid hormones including cortisol and testosterone in
the body. In previous clinical studies, the investigators have shown that the activity of 5αR
increases as you gain weight and decreases with weight loss. In addition, work that the
investigators have performed in the laboratory has shown that if you increase 5αR levels in
liver cell grown in the laboratory, the amount of fat that they contain increases. The
investigators would therefore like to demonstrate the effect of inhibition 5αR on the
regulation of insulin, glucose and fat in the body.