Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
A 9-week randomized double-blind, multi-center study of 172 patients, who after 1 week
baseline evaluation are randomized to either fixed dose pregabalin starting at 75 mg BID for
one week and increased to 150 mg BID for 7 weeks or flexibly dosed pregabalin given BID
(75-300 mg/d) increased gradually over 4 weeks then maintained at that same dosing for 4
weeks.It is proposed that use of flexible dosing combined with nightly dosing would have
similar pain relief to fixed dosing, would improve adherence, would have less side effects
and would be more likely to improve sleep.