Overview

Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

Status:
Completed

Trial end date:
2005-10-01

Target enrollment:

Participant gender:

Summary

RATIONALE: Drugs used in chemotherapy, such as fludarabine and chlorambucil, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known whether fludarabine is more effective than chlorambucil in treating chronic lymphocytic leukemia. PURPOSE: This randomized phase III trial is studying fludarabine to see how well it works as first-line therapy compared to chlorambucil in treating older patients with previously untreated chronic lymphocytic leukemia.

Phase:

Phase 3

Details

Lead Sponsor:

German CLL Study Group

Treatments:

Chlorambucil
Fludarabine
Fludarabine phosphate
Vidarabine