Fludeoxyglucose F 18 PET/CT Imaging in Finding Cancer in Patients Undergoing Surgery for Solid Tumors

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this pilot study is to evaluate a combined and integrated technological approach of 18F-FDG-directed perioperative PET/CT imaging and intraoperative handheld gamma probe detection of known and occult disease in patients undergoing surgery for solid malignancies.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ohio State University Comprehensive Cancer Center
• Treatments: Fluorodeoxyglucose F18

Criteria

Inclusion Criteria:

• Patients must be 18 years of age or older.

• Patients must either have a histologic-confirmed solid malignancy or have a suspected solid malignancy which has required a diagnostic preoperative PET/CT scan or for which a diagnostic preoperative PET/CT scan has been recommended

• Patients must clinically have been determined to be a candidate for the indicated surgical procedure.

• Patients may have had prior surgery and/or chemotherapy with no limit to the number of prior therapeutic procedures or chemotherapeutic regimens.

• Patients must have a performance status of 0, 1 or 2 by ECOG standards.

• Patients must give written informed consent, including consent to have IV line placed for 18F-FDG administration.

• Females of childbearing age must have a negative pregnancy test (by Beta HCG qualitative analysis), must have had a history of a surgical sterilization, or must give history of no menses in past twelve months.

• Fasting blood sugar less than 200 mg/dl.

Exclusion Criteria:

• Any patient with active CNS tumor involvement.

• Any patient who is pregnant or lactating.

• Any patient with a body size and habitus that is determined to prohibit use of the diagnostic equipment.

• Any patient with a tumor burden that is determined to be so great (as determined by preoperative PET/CT scanning or intraoperative findings) that further surgery is not advised.