Fludrocortisone, in association with hydrocortisone, has demonstrated an improvement in
survival in septic shock patients with relative adrenal insufficiency. However, the utility
of low doses of steroids and in particular of mineralocorticoids in septic shock is still
discussed.
The purpose of the investigators study is to investigate the effects of 3 increasing doses of
fludrocortisone (100 μg, 200 μg, 400 μg) in order to determine which dose allows the best
pressor response to phenylephrine in healthy volunteers, and simultaneously assess their
respective hemodynamic and biological effects.