Fludrocortisone's Test in Salt Sensitivity

• Status: Unknown status
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The main hypothesis of this study is look for a clinical and fast test to identify salt sensitivity by administration of fludrocortisone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Fludrocortisone

Criteria

Inclusion Criteria:

• Age 40 to 65 years

• Both sexes and all ethnicities;

• Body Mass Index (BMI) between 20 and 30 kg/m2;

• Patients with hypertension with systolic blood pressure (SBP) between 140 and 159 mmHg and diastolic blood pressure (DBP) between 90 mm Hg and 99 mm Hg, without medication or after four weeks of placebo

Exclusion Criteria:

• Moderate/severe hypertension (BP ≥ 160/100 mm Hg) or secondary cause of hypertension;

• Use of more than two antihypertensive classes at the time of selection;

• Presence of diabetes mellitus or other endocrine disorders;

• Presence of renal impairment (creatinine clearance <60 ml / min, calculated by Cockcroft-Gault formula);

• Presence of heart failure;

• Presence of cardiac arrhythmias;

• History of stroke, coronary heart disease (myocardial infarction, angina) and peripheral vascular insufficiency;

• Presence of liver failure;

• Alcoholism;

• Psychiatric disorders;

• Use of anovulatory or continuous use of other drugs, such as hormonal or nonhormonal anti-inflammatory drugs that may interfere with blood pressure.

• Pregnant women