Fluid Mobilization in Hospitalized Patients With Acute Kidney Injury
Status:
Completed
Trial end date:
2019-12-31
Target enrollment:
Participant gender:
Summary
Hospitalized patients often suffer from an acute shutdown of kidney function secondary to
infections, use of antibiotics, or use of intravenous contrast agents. This results in the
accumulation of toxic substances and retention of fluid in the body. Dialysis techniques are
often needed to manage these patients to remove the retained toxic substances and extra fluid
and allow the kidney time to recover. The amount and duration of fluid accumulation have been
associated with a higher risk of death and longer hospital stays. Correction of fluid
overload with dialysis has been shown to be beneficial in improving the outcomes from these
patients. Most patients are quite sick and often have low levels of a blood protein called
albumin that makes them more prone to developing low blood pressure during dialysis and
limits the ability of dialysis to remove solutes and fluid adequately. Often dialysis
sessions are complicated by the development of low blood pressures and symptoms such as
nausea, vomiting, and headaches that further compromises dialysis efficacy. In this study,
the hypothesis that addition of intravenous albumin during the dialysis session will improve
the ability to remove fluid and reduce the incidence of low blood pressure during dialysis
thereby improving patient tolerance and the efficacy of the procedure will be tested.
Patients with acute kidney failure or end-stage Renal Disease who need dialysis for fluid
removal will be allocated to receive albumin or saline as intravenous fluids during
individual dialysis sessions and information on how much fluid can be removed and how many
complications occur in each session will be recorded. Dialysis sessions with albumin will be
compared with those with saline alone to determine the benefit of adding albumin to the
treatment. Information obtained from this study will allow physicians to manage patients
requiring dialysis for acute kidney failure more effectively and help improve outcomes.