Fluid Volume-hypotension Association in Cesarean Under Neuraxial Anesthesia
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Hypotension resulted from neuraxial block is a common problem, of which is a special issue in
patients undergoing Cesarean section. A large number of studies and clinical guidelines
suggest that fluid loading, pre- or co-anesthesia, is a promising manner in preventing
hypotension. However, it is still a controversy because the fact of a relatively increased
blood volume in parturients. In addition, although it is effective of fluid management, it's
precise relationship between fluid (crystalloid or colloid) volume and the proportion of
hypotension in Cesarean patients under neuraxial anesthesia is still unknown. The
investigators designed this trial to clarify the accurate relationship between fluid volume
in an escalated manner and the occurrence of hypotension analyzed with a non-linear
regression, and wanted to present the 50% effective volume (EV50) of fluid including
crystalloid and colloid in preventing hypotension in patients undergoing Cesarean section.