Removing a tumor from your brain is hard to do because, very often, brain tumors do not have
boundaries that are easy for your surgeon to find. In many cases, the surgeon can't tell
exactly where the tumor begins or ends. The surgeon usually can remove most of your tumor by
looking at the MRI images that were taken of your brain before surgery. However, the surgeon
does not have any good way to tell if the entire tumor has been removed or not. Removing the
entire tumor is very important because leaving tumor behind may allow it to grow back which
could decrease your chances of survival.
It is possible to detect tumor cells by making them glow with a specific color of light (a
process called fluorescence). This can be done by having you take the drug, ALA, before your
surgery. ALA is a molecule that already exists in the cells of your body. Once enough of it
is in your body, it gets converted into another molecule named PpIX. If blue light is shined
on a tumor that has enough PpIX, it will glow with red light (fluorescence) that can be
detected with a special camera. In this study, we want to determine how the fluorescence (red
light) is related to the tumor which appears in the images that are normally taken of your
brain (which the surgeon uses to guide the removal of your tumor) and the tumor tissue that
will be removed during your surgery. Removing the entire tumor is very important because
leaving tumor behind may allow it to grow back which could decrease your chances of survival.
Phase:
Phase 1
Details
Lead Sponsor:
Dartmouth-Hitchcock Medical Center David W. Roberts
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)