Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism
Status:
Terminated
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
We will study patients with a current major depressive episode, comorbid alcoholism and a
history of a past suicide attempt. All subjects with alcohol dependence will be evaluated for
risk of alcohol withdrawal prior to randomization. The study will provide six months of
antidepressant pharmacotherapy as well as psychotherapy focused on alcohol relapse
prevention. Patients will also be encouraged to attend daily Alcoholics Anonymous meetings.
The outcome measures will be: 1) occurrence of suicide events; 2) reduction of suicidal
ideation; 3) reduction in neuropsychological measures of impulsivity.
Phase:
Phase 4
Details
Lead Sponsor:
National Institute on Alcohol Abuse and Alcoholism (NIAAA) New York State Psychiatric Institute
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)