Folic Acid Supplementation in Phenytoin Induced Gingival Overgrowth

• Status: Completed
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Phenytoin, a common anti-seizure drug, leads to cosmetically unacceptable side effect of gingival overgrowth in a significant number of patients. There is some evidence of therapeutic effect of folic acid in cases of established phenytoin induced gingival overgrowth. In this study, the aim is to study the prospective preventive effect of low dose oral folic acid supplementation on phenytoin induced gingival overgrowth in epileptic children.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: All India Institute of Medical Sciences, New Delhi
• Treatments: Folic Acid; Phenytoin; Vitamin B Complex

Criteria

Inclusion Criteria:

• Age: 6-15 yr

• Started on phenytoin within 1 mo of enrollment

Exclusion Criteria:

• Not willing to participate

• On other folic acid antagonists e.g. anti-neoplastic drugs for >/= 2 wks during last 3 months

• Pre-existing gingival over-growth due to other cause