Follow-up and Steroid Treatment Results in Intussusception

• Status: Recruiting
• Trial end date: 2027-12-24
• Target enrollment: 0
• Participant gender: All

Summary

Treatment interventions in the treatment of intussusception are hydrostatic or pneumatic reduction and manual reduction with laparotomy. In addition, it is known that in some of the ileoileal intussusception cases, intussusception disappears in short-term observation and it is an accepted treatment to follow-up for a while in ileoileal cases without making a decision for laparotomy. In a study we conducted, we reported that 17 of 81 patients had spontaneous opening with follow-up and no further treatment was required. The hydrostatic or pneumatic reduction has a 0.8% risk of bowel perforation, fever due to bacterial translocation is common, septicemia has also been reported and anal fissures due to catheterization is seen. Baby or child's stress, psychology, abdominal pain are other negative aspects that cannot be measured. Sonmez et al. reported that when a patient with HSP was diagnosed with intussusception while under steroid treatment, and when they took the patient to laparoscopy, they observed that the patient's intussusception was opened. In the same study, Sönmez et al. mentioned that they followed up 4 patients diagnosed with HSP by administering only steroid treatment and observed that intussusception was opened in 3 of these patients without the need for any other intervention.

The steroid is used as a single dose (1 mg/kg) in cases such as acute allergic reactions, bronchiolitis, asthma, laryngitis, edema treatment, bronchoscopy, intubation, extubation medication. When the literature is reviewed, it has been shown that single-dose, low-amount (1 mg/kg) steroid therapy does not have side effects. We predict that the steroid will reduce the thickening of Peyer's plaques with its anti-inflammatory effect, and relieve edema as in other areas of use, by relieving the congested intussusceptum. Thus, in infants and children, there will be no need for hydrostatic or pneumatic reduction, which has the risk of perforation and infection (septicemia) and exposure to radiation, and our patients will regain their health without the need to apply this interventional treatment.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Baskent University
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• who applied to Başkent University Ankara Hospital Pediatric Emergency Polyclinic,

• Diagnosed with intussusception by USG,

• Consulted with Pediatric Surgery

• Informed consent was obtained by explaining treatment options to their families.

Exclusion Criteria:

• Diffuse tenderness and defense on abdominal examination,

• The duration of the complaints exceeds 24 hours,

• When the intestinal blood supply is decreased in the ultrasound findings,

• Patients with free air on the standing abdominal X-ray,

• Patients with pathology requiring urgent surgical intervention