Food Effect Study on the Bioavailability and PK of PA-824 Tablets in Healthy Adult Subjects (CL-009)
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
This will be a Phase 1, single-center, randomized, balanced, single-dose, two-period,
two-sequence, crossover, open-label study to evaluate the effect of food on the
pharmacokinetics of PA-824. The hypothesis to be tested in this study is that the rate and
extent of absorption of two doses of PA-824 (50mg or 400 mg and 200mg) are the same after a
high-calorie, high-fat meal as compared with after a minimum 10-hour fast.
For each of the two dose levels 16 subjects with approximately 8 men and 8 women, will be
enrolled for a total of 32 subjects.