Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Improvements to treatment strategies for patients upper gastrointestinal cancers have
produced an increasing population of people who remain free from disease recurrence in the
long term. Weight loss and nutritional problems are common among patients who attain
long-term remission and cure after surgery for upper gastrointestinal cancers. However, the
mechanisms underlying these problems are not well understood. In this study the investigators
aim to determine whether reduced food intake after upper gastrointestinal surgery is caused
by early satiety related to exaggerated post-prandial gut hormone responses.
This is a randomized, double-blind, placebo controlled, crossover study of the effect of
100μg octreotide SC on ad libitum food intake in patients free from complications or
recurrence at least one year post-oesophagectomy, gastrectomy or pancreaticoduodenectomy. A
comparator group of age, weight and gender matched subjects will be studied concurrently, and
caloric intake and subjective symptom scores after administration of octreotide versus
placebo among surgical and comparator subjects will be assessed.
Phase:
N/A
Details
Lead Sponsor:
St. James's Hospital, Ireland
Collaborators:
Göteborg University University College Dublin University of Dublin, Trinity College