Forced Fluid Removal in High Risk Acute Kidney Injury

• Status: Terminated
• Trial end date: 2017-06-08
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this pilot trial is to assess the feasibility of forced fluid removal in patients admitted to the intensive care unit (ICU) with high-risk AKI and severe fluid overload. The intervention will use furosemide infusion and/or continuous renal replacement therapy (CRRT) to achieve and maintain a neutral cumulative fluid balance. The intervention will be compared to standard of care as reflected in the kidney disease improving global outcome (KDIGO) guidelines.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nordsjaellands Hospital
• Collaborators: Aalborg Universitetshospital; Aalborg University Hospital; Rigshospitalet, Denmark
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• Age ≥ 18 years of age

• Acute Kidney Injury defined according to the KDIGO criteria

• Renal Recovery Score ≤ 60%. (Calculated using www.renal-recovery-score.com)

• Fluid overload defined as a positive fluid balance ≥ 10% of ideal body weight.

• Able to undergo randomization within 12 hours of fulfilling other inclusion criteria

Exclusion Criteria:

• Known pre-hospitalization advanced chronic kidney disease. (eGFR < 30 mL/minute/1.73 m2 or chronic RRT.)

• Severe hypoxic respiratory failure (use of invasive ventilation and FiO2 > 80% and PEEP > 10 cm H2O)

• Severe burn injury (≥ 10% TBSA)

• Severe hypo- or hyper- natremia (< 120 or > 155 mmol/l)

• Hepatic coma

• Mentally disabled undergoing forced treatment

• Pregnancy/breast feeding

• Lack of commitment for on-going life support including RRT

• Lack of informed consent