Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Status:
Recruiting
Trial end date:
2028-07-01
Target enrollment:
Participant gender:
Summary
The overall objective of this project is to identify the key salt-sensing regions of the
brain and determine the underlying mechanism of sodium sensing. The investigators will assess
how the brain responds to an acute increase of salt in the blood using MRI. This will be done
during a 30-minute infusion of a saline solution containing 3% salt. One trial will be
conducted with a salt sensing channel blocker and one trial without the salt sensing channel
blocker. This will help to assess the role of a specific salt sensing channel in the brain.
Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will
be given food to consume for 7-days. Comparisons will be made between salt resistant (no
change in blood pressure going from low to high salt diets) and salt sensitive adults (a
change in blood pressure going from low to high salt diets). The investigators think the
changes in MRI will be greater in salt sensitive compared to salt resistant subjects.