Overview

Fractional CO2 Laser-assisted Cutaneous Delivery of Methotrexate Versus 5-fluorouracil in Stable Non-segmental Vitiligo

Status:
Not yet recruiting

Trial end date:
2023-04-01

Target enrollment:
0

Participant gender:
All

Summary

Vitiligo is a common acquired, depigmenting skin disease that affect the patient's psychological state and quality of life.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Assiut University

Treatments:

Fluorouracil
Methotrexate

Criteria

Inclusion Criteria:

The patients will be enrolled in the study if they have:

- Non-segmental vitiligo

- Stable disease (a patient reporting no new lesions, no progression of existing
lesions, and absence of Koebner phenomenon during the past 1 year)

Exclusion Criteria:

1. History of skin cancers, keloid, hypertrophic scars or photosensitivity.

2. Use of any topical medications, phototherapy, or laser for vitiligo within 1 month
prior to enrollment.

3. Renal, hepatic, hematological or debilitating chronic diseases.

4. Active inflammation or infection at site of treatment.

5. Pregnant and lactating females.

6. Age under 18 years old.

7. Segmental vitiligo, active or extensive disease.

8. Unrealistic expectation.