Freeze-dried Plasma in the Initial Management of Coagulopathy in Trauma Patients
Status:
Completed
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
Knowledge and management of bleeding in severe trauma has changed. A specific coagulopathy is
present in 40% of cases. It has a very early onset and this coagulopathy is associated with
increased mortality. It must be detected and treated early, as illustrated by the military
medical data, from the Iraq war and civilian medicine. However, fresh frozen plasma (FFP)
requires a thawing step.The French army has encouraged the development of a freeze-dried
plasma of innovative because viral inactivation and universal blood grouping, well tolerated,
with a reduced risk of TRALI. This sophisticated therapeutic product can be administered
after 6 minutes of reconstitution without the need for cross-matching. Nevertheless, its used
is currently reserved for military purpose in overseas operations and needs to be evaluated
for civil use. To this end, the investigators need to evaluate the impact on coagulopathy of
an immediate availability of plasma.