Frontal Electroencephalography of Neonatal Patients Under Sedation With Opioids and General Anesthesia With Propofol.

• Status: Recruiting
• Trial end date: 2022-01-03
• Target enrollment: 0
• Participant gender: All

Summary

Frequently, neonates hospitalized in neonatology units require anesthesia for surgery. The drugs used for this purpose are opioids and other anesthetics, such as propofol.

Currently, the administration of anesthesia is difficult in neonates due to the neurological immaturity of these patients, the scarcity of adequate pharmacological studies, the prolonged use of one or more sedatives prior to surgery and the limited usefulness of current anesthetic monitoring devices in this population.

Electroencephalography (EEG), which has allowed estimation of anesthetic depth in other populations, has been less explored in neonates. To date, there are no EEG markers, correlated with a given dose of anesthesia, that allow an adequate administration in this kind of patients. In this context, a better understanding of the anesthetic effect in the neonatal brain would allow defining characteristic EEG patterns, improving the estimation of anesthetic depth and anesthetic dosage in neonates.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pontificia Universidad Catolica de Chile
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Term newborns (>37 weeks) admitted to the NICU

• Diagnosis of surgical pathology, non-neurological, to be resolved in the NICU, in the next hours or days.

• Need for continuous sedation-analgesia prior to surgery.

Exclusion criteria:

• Perinatal asphyxia

• Evidence of severe neurological injury.

• Suspected or diagnosed brain malformations

• Uncontrolled metabolic and hemodynamic instability at the time of surgery.