Frontal Electroencephalography of Neonatal Patients Under Sedation With Opioids and General Anesthesia With Propofol.
Status:
Recruiting
Trial end date:
2022-01-03
Target enrollment:
Participant gender:
Summary
Frequently, neonates hospitalized in neonatology units require anesthesia for surgery. The
drugs used for this purpose are opioids and other anesthetics, such as propofol.
Currently, the administration of anesthesia is difficult in neonates due to the neurological
immaturity of these patients, the scarcity of adequate pharmacological studies, the prolonged
use of one or more sedatives prior to surgery and the limited usefulness of current
anesthetic monitoring devices in this population.
Electroencephalography (EEG), which has allowed estimation of anesthetic depth in other
populations, has been less explored in neonates. To date, there are no EEG markers,
correlated with a given dose of anesthesia, that allow an adequate administration in this
kind of patients. In this context, a better understanding of the anesthetic effect in the
neonatal brain would allow defining characteristic EEG patterns, improving the estimation of
anesthetic depth and anesthetic dosage in neonates.