Full-mouth Periodontal Debridement and Metronidazole Gel in Patients With Chronic Periodontitis
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Hypothesis: metronidazole gel applied topically after periodontal debridement in smokers
volunteers could improve clinical parameters when compared to metronidazole tablets +
periodontal debridement. Method: 30 smokers with chronic periodontitis were randomly assigned
into 3 groups: periodontal debridement combined with 3 g placebo gel; periodontal debridement
combined with daily topical application of 3 g metronidazole benzoate gel (15%); and
periodontal debridement combined with a daily single dose of 750 mg metronidazole. Clinical
parameters evaluated were visible plaque, gingival bleeding, probing pocket depth and
relative attachment level.