Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema
Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
This study will use dual energy x-ray computed tomography (DECT) to evaluate the relationship
between heterogeneous perfusion, hypoxia (low oxygen in inspired gas) and induction of
pulmonary vascular dilatation to characterize emphysema susceptibility in a normal smoking
population. The investigators will correlate DECT measures of perfusion with lung injury
measured by single photon emission computed tomography (SPECT). The investigators will study
the effect of pulmonary arterial vasodilation to see if it eliminates indices of persistent
lung injury in smokers that are susceptible to emphysema
Phase:
Phase 4
Details
Lead Sponsor:
Eric A. Hoffman University of Iowa
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) National Institutes of Health (NIH)