Functional Differences in Effortful Control

• Status: Active, not recruiting
• Trial end date: 0000-00-00
• Target enrollment: 180
• Participant gender: Both

Summary

The purpose of this study is to learn more about the brain circuits involved with effortful control in healthy adult participants. Study participants will be given either methylphenidate (also known as 'Ritalin')which is an FDA approved, most widely-used medication given to those diagnosed with Attention Deficit Hyperactivity Disorder (ADHD)or a placebo, which is a sugar pill. Each participant will also perform some computer tasks that have been shown in previous studies to require effortful control while undergoing an fMRI (functional Magnetic Resonance Imaging) which takes a special kind of picture of the brain. Our goal is to learn more about the brain mechanisms by which methylphenidate improves effortful control.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Michigan
• Treatments: Methylphenidate
• Last Updated: 2016-07-28

Criteria

Inclusion Criteria:

• Right-handedness

Exclusion Criteria:

• Any clinically significant personal or family history of cardiac problems

• Any current Axis I psychiatric disorder (diagnosis as verified by the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV)

• A previous adequate trial with methylphenidate (Ritalin)

• Currently taking any psychoactive medications

• Any clinically significant medical condition

• Any clinically significant neurological problem (seizures, tics, serious head injury)

• Contraindications to MRI (metal objects in body or claustrophobia)

• Currently pregnant or lactating

• Alcohol or substance abuse (current or in the past 2 years)

• Left-handedness or ambidextrous

• Liver or kidney disease