Functional Effects of Botox on the Brain Using MRS and fMRI
Status:
Completed
Trial end date:
2018-03-16
Target enrollment:
Participant gender:
Summary
The injection of BOTOX into peripheral muscles has been shown to have therapeutic effects in
a growing number of indications including disorders involving skeletal muscle (e.g.,
strabismus, blepharospasm, cervical dystonia, spasticity, cosmetic), smooth muscle (e.g.,
bladder), glands (axillary hyperhidrosis) and nociceptive pain (e.g. migraine) (Brin. 2014).
Recently, several studies have suggested that peripheral BOTOX injections in the region of
the glabellar lines (muscles around the eyes) may be effective in treating major depression
and chronic migraine. However, the mechanism underlying the effect of peripheral BOTOX
injections on the brain is not well understood. Therefore, the Investigators propose to
further explore the functional effects of BOTOX injections on brain in healthy controls. The
approach will involve the measurement of brain metabolites in the brainstem using MRS as well
as an investigation of the functioning and connectivity between regions of the brain using
resting state MRI and high resolution fMRI.