Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients

• Status: Recruiting
• Trial end date: 2021-07-30
• Target enrollment: 0
• Participant gender: All

Summary

Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation. Understanding how the brain controls cough and the urge-to-cough could lead to new cough suppressing therapies. The overall objective of this project is to use functional brain imaging (fMRI) to identify brain regions that are involved in the exaggerated urge-to-cough in humans with chronic cough. Our focus will be on the brainstem where information from the airways first arrives in the central nervous system.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Stuart Mazzone
• Collaborators: Imperial College London; Monash University; Queen's University, Belfast
• Treatments: Adenosine; Capsaicin

Criteria

Inclusion Criteria:

• Patients with physician diagnosed chronic refractory cough (cough lasting >8 weeks).

• > 18 years of age

• Must be cognitively impaired

Exclusion Criteria:

• People with contraindications to MRI scanning (i.e. metal implants, claustrophobia).

• History of uncontrolled asthma or chronic respiratory disease (other than refractory cough).

• Evidence of an allergic reaction to capsaicin (chilli).

• Pregnant women.

• Smoking, current or recent history (last 6 months).