Functional Sucrase Deficiency in Short Bowel Syndrome Patients With Intestinal Failure
Status:
Not yet recruiting
Trial end date:
2022-11-01
Target enrollment:
Participant gender:
Summary
Short gut syndrome with intestinal failure patients may have decreased production of
disaccharidases, like sucrase, an enzyme responsible for digesting sugar in foods. This can
happen due to loss of bowel length from surgery or from loss of cellular function in the
intestines due to use of parenteral nutrition intravenously. Therefore, patients with these
conditions may not be able to digest sucrose (sugar) fully. Patients might experience
abdominal distension/pain, vomiting and diarrhea when sugar is taken in orally or through the
g-tube, which can limit patients' ability to increase oral or g-tube feeds in short gut
syndrome patients with intestinal failure.
In patients with short gut syndrome and intestinal failure, the administration of exogenous
sucrase (enzyme) may improve sucrose (sugar) digestion and thus the ability to tolerate more
oral or g-tube feeds.