Overview

Functional and Structural Assessment of Endobronchial Valve Recipients Using Dynamic Hyperpolarized Xenon-129 MRI

Status:
Not yet recruiting

Trial end date:
2027-07-31

Target enrollment:

Participant gender:

Summary

We propose to use hyperpolarized xenon-129 Magnetic Resonance Imaging (MRI) to study lung function of COPD patients who will receive endobronchial valve (EBV) therapy as part of their clinical standard-of-care. Once inhaled, HP xenon can provide information to imagers regarding functionality across specific regions of the lungs through the assessment of the replacement of air during the normal breathing cycle, how much oxygen is in the airspaces, and if the normal spongy tissue structure has been compromised by lung disease. Pre- (baseline) and post-EBV (follow-up) lung function imaging with HP Xe will potentially lead to be better understand disease progression and treatment mechanism.

Phase:

Phase 1

Details

Lead Sponsor:

Xemed LLC

Collaborator:

University of Pennsylvania

Treatments:

Xenon