Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to verify if ethacrynic acid continuous infusion is superior to furosemide continuous infusion in total urine output production during the first 24 post operative hours.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bambino Gesù Hospital and Research Institute
• Treatments: Ethacrynic Acid; Furosemide

Criteria

Inclusion Criteria:

• Children with congenital heart disease undergoing cardiac surgery

• intraoperative aortic cross clamp over 90 minutes or interventional catheterization procedures with post-operative inotrope score over 20

• sign of fluid retention after surgical procedures

Exclusion Criteria:

• Preoperative renal dysfunction

• Preoperative administration of more than 4mg/kg/die loop diuretics

• Need for renal replacement therapy at ICU admission

• Need for ECMO at ICU admission