Furosemide and Creatinine Tubular Stress Test in Order to Measure Proximal Tubule Residual Function

• Status: Recruiting
• Trial end date: 2022-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a two phase study. The first part will take place at the National Institute of Cardiology in Mexico, the second phase will be made in collaboration with the University of California San Diego.

This is a non blind experimental study, 60 patients with different stages of CKD from the outpatient unit of the institute will be included. Each patient will receive a furosemide stress test of 1 mg/kg in non diuretic users and 1.5 mg/kg in diuretic users, in addition to an oral load of 5 grams of creatinine, as well as Iohexol to measure GFR. After the intervention blood and urine samples will be drawn at 10 minutes, 30 minutes, and every hour until the completion of the observation at 6 hours.

Blood and urine will be analized to measure creatinine (blood and urine), then samples will be processed for measurement of furosemide (mass spectometry), indoxyl sulphate, p-cresol, hippurate, and uromoduline.

The aim of this stiudy is to asses the differences between GFR and proximal tubule function.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Instituto Nacional de Cardiologia Ignacio Chavez
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• Patients older than 18 years old.

• Patients with CKD that attends to the outpatient clinic.

• Residual uresis of 500 mL

Exclusion Criteria:

• Patients younger than 18 years old.

• Increase of Cr in a rate of 0.5 mg/dL, or loss of more than 30% of previous GFR.

• Patients with cardiorrenal syndrome type 1.

• Patients with dilated miocardiopathy.

• Volume overload.