Alcoholic hepatitis is related to very high mortality rate. About 40% of the patients are
died within first 6 months after the detection of the clinical syndrome. Therefore, it is
very essential for proper diagnosis and early treatment. In response to acute or chronic
liver damage, bone marrow derived stem cells can spontaneously populate liver and
differentiate into hepatic cells. Animal and human studies suggested that injured hepatocyte
may be replaced by pluripotent bone marrow cells. However, this hepatocyte repopulation is
highly dependent on varieties of liver injury and therapeutic conditions. The studies has
suggested Granulocyte-colony stimulating factors (G-CSF) can regenerate hepatocyte by fusing
with hematopoietic cells, thereby enhancing the liver histology and survival rate.
G-CSF is a cytokine capable to regulate a number of functions in neutrophils. In three recent
studies mobilization of bone marrow stem cells induced by G-CSF was observed in patients with
alcoholic hepatitis. In two of this studies there was a survival benefit with the use of
G-CSF.
Therefore we plan to study the safety and efficacy of G-CSF in the patients with alcoholic
hepatitis.
Phase:
Phase 4
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research