GLP-1 and Hypoglycemia

• Status: Active, not recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels. The purpose of this study is to learn if and how glucagon-like peptide-1 (GLP-1; a naturally occurring hormone in the gut) changes the effects that low blood sugar levels have on blood vessels.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Maryland; University of Maryland, Baltimore
• Treatments: Glucagon; Glucagon-Like Peptide 1

Criteria

Inclusion Criteria:

• 14 (7 males, 7 females) healthy controls age 30-60 yr.

• 14 (7 males, 7 females) people with type 2 DM age 30-60 yr.

• For type 2 DM: HbA1c 6-10.0%

• No significant diabetic tissue complications (i.e. history of retinopathy, neuropathy, stasis ulcers, etc.)

• Body mass index >25kg • m-2

Exclusion Criteria:

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