GP VS TP in the Treatment of Advanced Nasopharyngeal Carcinoma in Northwest China

• Status: Completed
• Trial end date: 2013-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study is a randomized, control, phase II study of locally advanced nasopharyngeal carcinoma (NPC) in Northwest China treated with Gemcitabine plus cisplatin regimen (GP) or Docetaxel plus cisplatin regimen (TP) induction chemotherapy followed by concurrent chemoradiotherapy. The population consists of stage III-IVb nasopharyngeal carcinoma (NPC). The effectiveness, side effects and quality of life will be evaluated according to Standard WHO response criteria, NCI-CTC AE V3.0 and EORTC QLQ-C30 and H&N35 questionnaire.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Air Force Military Medical University, China; Fourth Military Medical University
• Treatments: Cisplatin; Docetaxel; Gemcitabine

Criteria

Inclusion Criteria:

• Histologically proven WHO II~III native NPC in northwest region of China;

• 18 Years to 70 Years;

• stages III-IVb according to AJCC stage classification(7th edition), no previous chemotherapy and radiotherapy;

• Performance status: 0-1(ECOG);

• WBC > 4.0X109/L, PLT > 100X109/L, with normal hepatic function(AST, ALT < 2.5 x upper limit of normal, and bilirubin < 1.5 x upper limit of normal), with normal renal function (Creatinine < 1.5 x upper limit of normal);

• Ability to comply with trial requirements.

Exclusion Criteria:

• Evidence of metastases by clinical or radiographic examinations;

• History of malignancy;

• Prior chemotherapy or anticancer biologic therapy for any type of cancer, or prior radiotherapy to the head and neck region except for radioactive iodine therapy.;

• Patients with uncontrolled intercurrent disease;

• Patients with currently active malignancy;

• Pregnant or lactating women patients of childbearing potential who are unwilling to practice adequate contraception during study treatment and for two months after the last administration of study drug.