GPI 15715 For Sedation in the Intensive Care Unit (ICU) Setting
Status:
Completed
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
Patients who are in the intensive care unit after surgery and require mechanical breathing
support (intubation and ventilation) usually require sedation to avoid agitation and
excessive stress responses. Short-acting sedatives such as midazolam and propofol are the
drugs typically used for this. Propofol provides for fast sedation and fast recovery from
sedation. Midazolam is slower to sedation and slower for recovery, but may provide some
advantages over propofol, such as a lower incidence of hypotension (low blood pressure). This
study will look at propofol compared to a product with fast sedation and recovery like that
of propofol but with less of a chance for hypotension like with midazolam. Patients will be
treated with the product for up to 8 hours and then will be monitored for 8 hours following
treatment.