Gabapentin Regimens and Their Effects on Opioid Consumption
Status:
Completed
Trial end date:
2019-04-24
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the best strategy of administering gabapentin in
connection with our current approach to perioperative pain management. We aim to evaluate two
different adjunct gabapentin regimens given in the perioperative period, and to identify
which manages patient pain more effectively and safely. In this evaluation, we will identify
the quantity of patients' opioid consumption, the quality of their pain management, and the
frequency and severity of any side effects they might experience.
Patients who are undergoing total knee replacement (TKR) and choose to participate will be
randomly assigned to a treatment group using computer-generated randomization. Patients in
group 1 (the control group) will receive the standard of care as pertains to gabapentin. This
consists of a single 600 mg dose of gabapentin administered to the patient approximately one
to two hours before surgery, then a dose of 600 mg each morning during postoperative
admission. Patients in Group 2 will receive 600 mg preoperatively, plus an additional
postoperative gabapentin regimen: they will take 300 mg of gabapentin every 8 hours for 1
week, then a single nightly dose of 300 mg for another month.